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Yoda1 + TRAIL apoptotic pathway. (A) Yoda1 is able to activate Piezo1, a mechanosensitive ion channel, under static conditions. This leads to Ca 2+ influx and a signaling cascade that enhances TRAIL-induced permeabilization of the mitochondria, resulting in increased apoptosis. (B) GsMTx-4 inhibits Piezo1 and other mechanosensitive ion channels, decreasing Ca 2+ influx and the synergistic effects of Yoda1. (C) Calpeptin inhibits calpain, decreasing the effect of extracellular Ca 2+ and leading to increased cell viability following treatment. (D) <t>Bax</t> <t>channel</t> <t>blocker</t> <t>(BCB)</t> inhibits Bax, blocking the effects of both Yoda1 and TRAIL, largely increasing cell viability.
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Yoda1 + TRAIL apoptotic pathway. (A) Yoda1 is able to activate Piezo1, a mechanosensitive ion channel, under static conditions. This leads to Ca 2+ influx and a signaling cascade that enhances TRAIL-induced permeabilization of the mitochondria, resulting in increased apoptosis. (B) GsMTx-4 inhibits Piezo1 and other mechanosensitive ion channels, decreasing Ca 2+ influx and the synergistic effects of Yoda1. (C) Calpeptin inhibits calpain, decreasing the effect of extracellular Ca 2+ and leading to increased cell viability following treatment. (D) Bax channel blocker (BCB) inhibits Bax, blocking the effects of both Yoda1 and TRAIL, largely increasing cell viability.

Journal: ACS Omega

Article Title: Chemical Activation and Mechanical Sensitization of Piezo1 Enhance TRAIL-Mediated Apoptosis in Glioblastoma Cells

doi: 10.1021/acsomega.3c00705

Figure Lengend Snippet: Yoda1 + TRAIL apoptotic pathway. (A) Yoda1 is able to activate Piezo1, a mechanosensitive ion channel, under static conditions. This leads to Ca 2+ influx and a signaling cascade that enhances TRAIL-induced permeabilization of the mitochondria, resulting in increased apoptosis. (B) GsMTx-4 inhibits Piezo1 and other mechanosensitive ion channels, decreasing Ca 2+ influx and the synergistic effects of Yoda1. (C) Calpeptin inhibits calpain, decreasing the effect of extracellular Ca 2+ and leading to increased cell viability following treatment. (D) Bax channel blocker (BCB) inhibits Bax, blocking the effects of both Yoda1 and TRAIL, largely increasing cell viability.

Article Snippet: Yoda1, Calpeptin, and Bax channel blocker (BCB) were obtained from Tocris Bioscience (Bristol, United Kingdom).

Techniques: Blocking Assay

Cell viability after inhibition of the Yoda1 + TRAIL apoptotic pathway. (A) The effect of GsMTx-4 on Piezo1 represented by the normalized Ca 2+ influx in GBM cells following GsMTX-4 inhibition. (B) The effect of calpeptin (Calp) on the Yoda1 + TRAIL apoptotic pathway represented via GBM mitochondrial depolarization. (C) The effect of BCB on the Yoda1 + TRAIL apoptotic pathway represented via GBM mitochondrial depolarization. No significance (ns), * p < 0.05, ** p < 0.01, *** p < 0.005, **** p < 0.001.

Journal: ACS Omega

Article Title: Chemical Activation and Mechanical Sensitization of Piezo1 Enhance TRAIL-Mediated Apoptosis in Glioblastoma Cells

doi: 10.1021/acsomega.3c00705

Figure Lengend Snippet: Cell viability after inhibition of the Yoda1 + TRAIL apoptotic pathway. (A) The effect of GsMTx-4 on Piezo1 represented by the normalized Ca 2+ influx in GBM cells following GsMTX-4 inhibition. (B) The effect of calpeptin (Calp) on the Yoda1 + TRAIL apoptotic pathway represented via GBM mitochondrial depolarization. (C) The effect of BCB on the Yoda1 + TRAIL apoptotic pathway represented via GBM mitochondrial depolarization. No significance (ns), * p < 0.05, ** p < 0.01, *** p < 0.005, **** p < 0.001.

Article Snippet: Yoda1, Calpeptin, and Bax channel blocker (BCB) were obtained from Tocris Bioscience (Bristol, United Kingdom).

Techniques: Inhibition

Journal: iScience

Article Title: Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death

doi: 10.1016/j.isci.2023.107916

Figure Lengend Snippet:

Article Snippet: Bax Channle Blocker , Tocris , No. 2160.

Techniques: Labeling, Recombinant, Software